Breast Cancer is the most common cancer in the UK and the second most common cause of cancer deaths for women in the UK, with over 48,000 deaths every year. Fortunately, treatment, surgical procedures and detection have improved in the last decades so that the breast cancer survival rate has steadily increased. The aim of our team of molecular biologists, medical oncologists, clinicians and pathologists is to continue and further accelerate this trend.
More details of SEARCHBreast, a resource to facilitate sharing of archived material derived from in vivo breast cancer models, can be found here: https://searchbreast.org/
Working towards better breast cancer survival rates
Our research focuses on a wide range of breast cancer-related issues, including:
- Normal mammary gland morphogenesis
- Stromal-epithelial interactions
- Kinase signalling
- Transcriptional regulation
- Migration, invasion and metastasis formation
- Innovative therapeutic approaches
The following funding agencies sponsor our work:
Some recent publications:
Ferrari N, McDonald L, Morris JS, Cameron ER and Blyth K (2013). RUNX2 in mammary gland development and breast cancer. J Cell Physiol. 2012 Nov 20. doi: 10.1002/jcp.24285. [Epub ahead of print]
McAlpine, F., Williamson,L.E., Tooze,S.A., Chan, E.Y.W. Regulation of nutrient-sensitive autophagy by uncoordinated-51 like kinases 1 and 2. Autophagy (2013) In Press.
Mleczak, A., Millar,S., Tooze, S.A, Olson, M.F, Chan, E.Y.W. Regulation of autophagosome formation by Rho kinase. Cell Signal. 25 (2013), pp. 1-11 DOI: 10.1016/j.cellsig.2012.09.010 (2013).