Our Researchers

Here you will find a profile of each of our Centre researchers detailing their research interests, key publications and contact details.

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    Alison Michie

    Molecular Lymphopoiesis
    Institution: University of Glasgow Area of interest:

    Focusing on the molecular events that induce haemopoietic stem cells (HSCs) to commit and differentiate towards the B and T lymphocyte lineages.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Alison Michie

    Leukaemia
    University of Glasgow
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    Alistair Boyer

    Institution: University of Glasgow Area of interest: Teams: Chemical Biology Team Publications:

    Alistair Boyer

    Chemical Biology
    University of Glasgow
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    Allan Watson

    Pure & Applied Chemistry
    Institution: University of Strathclyde Area of interest:

    Research interests are in the area of organic synthesis and methodology, particularly in the area of catalysis.

    Teams: Chemical Biology Team Publications:

    Allan Watson

    Chemical Biology
    University of Strathclyde
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    Andrew Biankin

    Translational Research
    Institution: University of Glasgow Area of interest:

    Research goals are to improve outcomes for individuals with pancreatic cancer through the development of early detection and novel therapeutic strategies based on molecular phenotyping and the delineation and implementation of biomarkers that facilitate clinical decision-making.

    CENTRE LEAD

    Teams: Pancreatic Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Andrew Biankin

    Pancreatic Cancer
    University of Glasgow
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    Andrew Sutherland

    Institution: University of Glasgow Area of interest:

    Research in the Sutherland group focuses on the development and understanding of new organic reactions with particular emphasis on using transition metal catalysis to create new chiral molecules.

    Teams: Chemical Biology Team Publications:

    Andrew Sutherland

    Chemical Biology
    University of Glasgow
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    Andy Paul

    Cellular Signalling
    Institution: University of Strathclyde Area of interest:

    The role of the inhibitory kappaB kinases (IKKs) in the regulation of both Nuclear Factor kappaB (NFkappaB)-dependent and -independent transcription in mediating inflammatory-based responses relevant to infection, regulation of immunity, cardiovascular disease and cancer.

    Teams: Breast Cancer Team Publications:

    See Selected Publications

    Andy Paul

    Breast Cancer
    University of Strathclyde
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    Anthony Chalmers

    Glioblastoma Therapy
    Institution: University of Glasgow Area of interest:

    Glioblastoma is the commonest and most aggressive primary brain tumour and is often refractory to conventional cancer treatments. The ultimate aim of our research group is to improve outcomes for patients with these tumours by overcoming their inherent resistance to radiotherapy and chemotherapy.

    Teams: Mesothelioma Team Brain Tumours Team Publications:

    Link to Enlighten, University of Glasgow

    Anthony Chalmers

    Brain Tumours, Mesothelioma
    University of Glasgow
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    Blair Johnston

    Computational Modelling
    Institution: University of Strathclyde Area of interest:

    Drug discovery, molecular structure simulation, machine learning and prediction, data analysis, and web-enabled science and collaboration tools.

    Teams: Chemical Biology Team Publications:

    See Selected Publications

    Blair Johnston

    Chemical Biology
    University of Strathclyde
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    Chris Halsey

    Institution: University of Glasgow Area of interest:

    Investigating mechanisms of central nervous system disease in childhood acute lymphoblastic leukaemia (ALL) and ways to reduce treatment related toxicity in this condition.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Chris Halsey

    Leukaemia
    University of Glasgow
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    Christine Dufès

    Formulation of nanomedicines
    Institution: University of Strathclyde Area of interest:

    - Design and development of novel tumour-targeted anti-cancer nanomedicines

    - Design and development of novel nanomedicines able to reach the brain after intravenous administration, with the ultimate aim to facilitate drug and gene delivery to brain tumours

    Teams: Prostate Cancer Team Brain Tumours Team Publications:

    Link to publications

    Christine Dufès

    Brain Tumours, Prostate Cancer
    University of Strathclyde
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    Colin Gibson

    Institution: University of Strathclyde Area of interest: Teams: Chemical Biology Team Publications:

    Colin Gibson

    Chemical Biology
    University of Strathclyde
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    Colin Steele

    Institution: NHS Greater Glasgow and Clyde Area of interest: Teams: Pancreatic Cancer Team Publications:

    Colin Steele

    Pancreatic Cancer
    NHS Greater Glasgow and Clyde
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    Craig Dick

    Histopathology
    Institution: NHS Greater Glasgow and Clyde Area of interest:

    Intrathoracic malignancies including lung cancer and mesothelioma.

    Teams: Mesothelioma Team Publications:

    Craig Dick

    Lung cancer, Mesothelioma
    NHS Greater Glasgow and Clyde
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    Craig Jamieson

    Medicinal Chemistry
    Institution: University of Strathclyde Area of interest:

    Programmes centred around hit and lead identification on disease targets and mechanisms, particularly in diseases of ageing.

    Teams: Chemical Biology Team Publications:

    Link to Publications

    Craig Jamieson

    Chemical Biology
    University of Strathclyde
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    Daniel Murphy

    Oncogene-Induced Vulnerabilities
    Institution: CRUK Beatson Institute, University of Glasgow Area of interest:

    The oncogene-induced alterations selectively required by cancer cells to maintain viability.

    Teams: Mesothelioma Team Pancreatic Cancer Team Publications:

    See Recent Publications

    Daniel Murphy

    Mesothelioma, Pancreatic Cancer
    CRUK Beatson Institute, University of Glasgow
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    Dave Bryant

    Molecular Control of Epithelial Polarity
    Institution: CRUK Beatson Institute, University of Glasgow Area of interest:

    Control of cell polarity in prostate cancer, part the role played by ARF GTPases and the cell surface protein Podocalyxin.

    Teams: Prostate Cancer Team Publications:

    See Recent Publications

    Dave Bryant

    Prostate Cancer
    CRUK Beatson Institute, University of Glasgow
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    David Chang

    Translational Research
    Institution: University of Glasgow Area of interest:

    The development and implementation of stratified medicine through molecular phenotyping using both tissue- and genomic-based assays.

    Teams: Pancreatic Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    David Chang

    Pancreatic Cancer
    University of Glasgow
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    David Flint

    Biochemistry
    Institution: University of Strathclyde Area of interest:

    IGFBP-5, which is highly expressed during development and plays a fundamental role in epithelial-mesenchymal interactions in the embryo.

    Teams: Breast Cancer Team Publications:

    See Selected Publications

    David Flint

    Breast Cancer
    University of Strathclyde
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    David France

    Institution: University of Glasgow Area of interest: Teams: Chemical Biology Team Publications:

    David France

    Chemical Biology
    University of Glasgow
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    David Irvine

    Institution: University of Glasgow Area of interest: Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    David Irvine

    Leukaemia
    University of Glasgow
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    Edmond Chan

    Institution: University of Strathclyde Area of interest:

    Regulation of autophagy by the mTORC1-ULK pathway.

    Teams: Breast Cancer Team Publications:

    See Selected Publications

    Edmond Chan

    Breast Cancer
    University of Strathclyde
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    Emma Shanks

    RNAi Screening
    Institution: CRUK Beatson Institute Area of interest:

    Facilitating the translation of existing cancer research into cancer treatments, and enhancing the efficacy of existing cancer drugs, potentially through a combinatorial therapeutic approach.

    Teams: Breast Cancer Team Publications:

    See Recent Publications

    Emma Shanks

    Breast Cancer
    CRUK Beatson Institute
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    Ewan Cameron

    Institution: University of Glasgow Area of interest: Teams: Breast Cancer Team Publications:

    Ewan Cameron

    Breast Cancer
    University of Glasgow
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    Gaurav Malviya

    Nuclear Imaging
    Institution: CRUK Beatson Institute Area of interest:

    Preclinical PET/MRI imaging of cancer using specific probes that allows non-invasive longitudinal assessment of biological processes, such as tumour metabolism, cell proliferation, angiogenesis, hypoxia and receptor dynamics.

    Teams: Publications:

    See PublicationsList.org

    Gaurav Malviya

    CRUK Beatson Institute
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    Glenn Burley

    Institution: University of Strathclyde Area of interest:

    The chemistry and biology of nucleotides, nucleic acids and nucleic acid binding molecules.

    Teams: Chemical Biology Team Publications:

    Link to Publications

    Glenn Burley

    Chemical Biology
    University of Strathclyde
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    Heather Jørgensen

    Chronic Myeloid Leukaemia Therapeutics
    Institution: University of Glasgow Area of interest:

    Studying quiescent leukaemic stem cells in order to find ways to overcome resistance to chemotherapy in CML.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Heather Jørgensen

    Leukaemia
    University of Glasgow
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    Helen Wheadon

    Haemopoietic Stem Cells
    Institution: University of Glasgow Area of interest:

    Study of the developmental pathways involved in normal and aberrant haemopoietic stem cells.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Helen Wheadon

    Leukaemia
    University of Glasgow
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    Hing Leung

    Prostate Cancer Biology, Urological Surgery
    Institution: CRUK Beatson Institute Area of interest:

    The significance of the FGF and ERK5 signalling pathways in prostate cancer.

    Teams: Prostate Cancer Team Publications:

    See Recent Publications

    Hing Leung

    Prostate Cancer
    CRUK Beatson Institute
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    Iain MacPherson

    Institution: CRUK Beatson Institute, University of Glasgow Area of interest:

    Rab-coupling protein (RCP)-mediated receptor trafficking in breast cancer progression.

    Teams: Breast Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Iain MacPherson

    Breast Cancer
    CRUK Beatson Institute, University of Glasgow
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    Iain McNeish

    Gynaecological Oncology
    Institution: University of Glasgow Area of interest:

    Treatment of ovarian cancer.

    Teams: Ovarian Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Iain McNeish

    Ovarian Cancer
    University of Glasgow
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    Imran Ahmad

    Bladder cancer, Prostate cancer, Urology
    Institution: University of Glasgow Area of interest:

    Understanding how aberrant signalling drives both bladder and prostate carcinogenesis.

    Teams: Prostate Cancer Team Publications:

    Rajan, P. et al. (2014) Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy. European Urology, 66(1), pp. 32-39.

    Stockley, J., Villasevil, M. E. M., Nixon, C., Ahmad, I., Leung, H., and Rajan, P. (2014) The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer. RNA Biology, 11(6), pp. 1-11.

    Imran Ahmad

    Prostate Cancer
    University of Glasgow
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    Jeff Evans

    Translational Cancer Therapeutics
    Institution: CRUK Beatson Institute, University of Glasgow Area of interest:

    Using transgenic models of pancreatic cancer to  determine how potential anti-cancer agents might best be evaluated in subsequent clinical trials.

    CENTRE LEAD

    Teams: Pancreatic Cancer Team Publications:

    See Recent Publications

    Jeff Evans

    Pancreatic Cancer
    CRUK Beatson Institute, University of Glasgow
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    Jen Morton

    Preclinical Trials
    Institution: CRUK Beatson Institute Area of interest:

    Our research focuses mainly on:
    (a) Investigating the importance of mutations found in human pancreatic tumours using mouse models.
    (b) Profiling different genetic subsets of pancreatic cancer to better understand the disease and identify specific targets for therapy.
    (c) Preclinical trials of targeted therapies in clinically and genetically relevant pancreatic cancer mouse models.

    Teams: Pancreatic Cancer Team Publications:

    Link to ORCID

    Jen Morton

    Pancreatic Cancer
    CRUK Beatson Institute
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    Jim Norman

    Integrin Cell Biology
    Institution: CRUK Beatson Institute Area of interest:

    The contribution of Rab-regulated integrin trafficking to cancer cell migration.

    Teams: Breast Cancer Team Publications:

    See Recent Publications

    Jim Norman

    Breast Cancer
    CRUK Beatson Institute
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    Joanna Morris

    Veterinary Oncology
    Institution: University of Glasgow Area of interest:

    Mammary gland development of the mouse as a model system for mammary neoplasia.

    Teams: Breast Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Joanna Morris

    Breast Cancer
    University of Glasgow
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    Joanne Edwards

    Translational Cell Signalling‌
    Institution: University of Glasgow Area of interest:

    Investigation of signal transduction mechanisms associated with the development and progression of breast, colorectal, renal and prostate cancer.

    Teams: Prostate Cancer Team Breast Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Joanne Edwards

    Breast Cancer, Prostate Cancer
    University of Glasgow
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    Joëlle Prunet

    School of Chemistry
    Institution: University of Glasgow Area of interest:

    The main research interest of the Prunet group is the synthesis of biologically active natural products, especially anticancer agents, and the development of new synthetic methodologies in organic chemistry. We are also working on new methods for conjugating small-molecule drugs with biocompatible polymers for drug delivery.

    Teams: Chemical Biology Team Publications:

    List of publications (ResearcherID)

    Joëlle Prunet

    Chemical Biology
    University of Glasgow
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    Jonathan Percy

    Institution: University of Strathclyde Area of interest: Teams: Chemical Biology Team Publications:

    Jonathan Percy

    Chemical Biology
    University of Strathclyde
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    Jurre Kamphorst

    Cancer Metabolomics
    Institution: CRUK Beatson Institute, University of Glasgow Area of interest:

    Targeting cancer-specific metabolic alterations.

    Teams: Pancreatic Cancer Team Publications:

    Link to PubMed

    Jurre Kamphorst

    Pancreatic Cancer
    CRUK Beatson Institute, University of Glasgow
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    Justin Bower

    Chemistry
    Institution: CRUK Beatson Institute Area of interest: Teams: Chemical Biology Team Publications:

    Justin Bower

    Chemical Biology
    CRUK Beatson Institute
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    Karen Blyth

    Transgenic Models
    Institution: CRUK Beatson Institute Area of interest:

    The role of RUNX2 in metastatic breast and prostate cancer.

    Teams: Breast Cancer Team Publications:

    See Recent Publications

    Karen Blyth

    Breast Cancer
    CRUK Beatson Institute
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    Karen Keeshan

    Paediatric and Adult Acute Leukaemias
    Institution: University of Glasgow Area of interest:

    The study of normal and malignant haematopoiesis.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Karen Keeshan

    Leukaemia
    University of Glasgow
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    Karin Oien

    Systems Pathology of Cancer
    Institution: University of Glasgow Area of interest:

    Pathology of gastro-intestinal and liver disease, especially cancer.

    Teams: Pancreatic Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Karin Oien

    Pancreatic Cancer
    University of Glasgow
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    Kevin Blyth

    Pleural Disease, Pulmonology, Respiratory Medicine
    Institution: NHS Greater Glasgow and Clyde, Pleural Disease Unit Queen Elizabeth University Hospital Area of interest:

    Translational research focused on novel blood, imaging and physical biomarkers of pleural malignancy, particularly Mesothelioma, and Lung Cancer. Our imaging research is centred around Magnetic Resonance Imaging. Clinical trial portfolio includes studies in diagnostics, imaging, intra-pleural therapy and pleurodesis. Additional areas of interest include Interventional Pulmonology.

    Teams: Mesothelioma Team Publications:

    Link to PubMed

    Kevin Blyth

    Lung cancer, Mesothelioma
    NHS Greater Glasgow and Clyde, Pleural Disease Unit Queen Elizabeth University Hospital
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    Laura Machesky

    Invasion and Metastasis, Migration
    Institution: CRUK Beatson Institute Area of interest:

    The control and mechanisms of actin assembly in various normal and cancer cells.

    Teams: Pancreatic Cancer Team Breast Cancer Team Publications:

    See Recent Publications

    Laura Machesky

    Breast Cancer, Pancreatic Cancer
    CRUK Beatson Institute
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    Mark Dufton

    Bioinformatics, Snake venom chemistry
    Institution: University of Strathclyde Area of interest: Teams: Chemical Biology Team Publications:

    Mark Dufton

    Chemical Biology
    University of Strathclyde
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    Mhairi Copland

    Leukaemia Stem Cell Self-Renewal
    Institution: University of Glasgow Area of interest:

    The abnormalities of stem cell self-renewal and bone marrow microenvironment that develop in myeloid leukaemias.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Mhairi Copland

    Leukaemia
    University of Glasgow
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    Mike Olson

    Molecular Cell Biology
    Institution: CRUK Beatson Institute Area of interest:

    Characterising how Rho GTPase signalling pathways contribute to cancer.

    Teams: Pancreatic Cancer Team Breast Cancer Team Publications:

    See Recent Publications

    Mike Olson

    Breast Cancer, Pancreatic Cancer
    CRUK Beatson Institute
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    Nick Tomkinson

    Chemical Biology, Synthetic Chemistry
    Institution: University of Strathclyde Area of interest:

    Research within the group is split into two distinct areas. The development of practical synthetic methodology and the preparation of tool compounds of biological relevance. Our approach to discovery in each of these areas is driven by mechanistic knowledge and understanding.

    Teams: Chemical Biology Team Publications:

    Link to Publications

    Nick Tomkinson

    Chemical Biology
    University of Strathclyde
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    Nigel Jamieson

    Surgery
    Institution: University of Glasgow Area of interest:

    Upper GI surgery and pancreaticobiliary disease.

    Teams: Pancreatic Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Nigel Jamieson

    Pancreatic Cancer
    University of Glasgow
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    Nigel Pyne

    Molecular Pharmacology
    Institution: University of Strathclyde Area of interest:

    The molecular mechanisms by which lysolipid receptors regulate cell biology.

    Teams: Breast Cancer Team Publications:

    See Selected Publications

    Nigel Pyne

    Breast Cancer
    University of Strathclyde
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    Owen Sansom

    Colorectal Cancer and Wnt Signalling
    Institution: CRUK Beatson Institute Area of interest:

    Use of novel inducible models of intestinal tumourigenesis to study the functions of specific tumour suppressor genes.

    CENTRE LEAD

    Teams: Prostate Cancer Team Pancreatic Cancer Team Publications:

    See Recent Publications

    Owen Sansom

    Pancreatic Cancer, Prostate Cancer
    CRUK Beatson Institute
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    Peter D Adams

    Epigenetics of cancer and ageing
    Institution: CRUK Beatson Institute, University of Glasgow Area of interest:

    The Adams lab is interested in the epigenetics of ageing and cancer. In particular, we are interested in age-associated epigenetic changes that predispose to cancer.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Peter D Adams

    Intestinal/colon cancer, Leukaemia, Melanoma
    CRUK Beatson Institute, University of Glasgow
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    Rachana Patel

    Institution: CRUK Beatson Institute Area of interest: Teams: Prostate Cancer Team Publications:

    Rachana Patel

    Prostate Cancer
    CRUK Beatson Institute
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    Richard Hartley

    Chemical Biology
    Institution: University of Glasgow Area of interest:

    We develop mitochondria-targeted probes for understanding the role of this metabolic and signalling hub in cancer. The probes include sensors, fluorophores and photo-activated and ROS-activated prodrugs.

    Teams: Chemical Biology Team Publications:

    Link to ORCID

    Richard Hartley

    Chemical Biology
    University of Glasgow
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    Rob Jones

    Clinical Trials
    Institution: University of Glasgow Area of interest:

    Optimising the use of chemotherapy in prostate cancer.

    Teams: Clinical Trials Team Prostate Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Rob Jones

    Clinical Trials, Prostate Cancer
    University of Glasgow
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    Rob Liskamp

    Chemical Biology, Medicinal Chemistry
    Institution: University of Glasgow Area of interest:

    Research in the Liskamp group is directed towards the creation of molecules that can be used to obtain insights into diseases such as infections and cancer, which may also lead to new approaches for their treatment.

    Teams: Chemical Biology Team Publications:

    ResearcherID

    Rob Liskamp

    Chemical Biology
    University of Glasgow
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    Robin Plevin

    Pharmacology
    Institution: University of Strathclyde Area of interest:

    Pharmacology of drugs in cancer.

    Teams: Prostate Cancer Team Publications:

    See Publications

    Robin Plevin

    Prostate Cancer
    University of Strathclyde
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    Sally Pimlott

    Radiopharmaceuticals
    Institution: University of Glasgow Area of interest:

    The development and utility of novel PET/SPECT radiopharmaceuticals in both clinical and preclinical research studies.

    Teams: Publications:

    Link to Enlighten, University of Glasgow

    Sally Pimlott

    University of Glasgow
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    Sara Zanivan

    Angiogenesis, Proteomics
    Institution: CRUK Beatson Institute Area of interest:

    Using state-of-the-art mass spectrometry and quantitative proteomics to study the complex molecular mechanisms regulating endothelial cells during angiogenesis.

    Teams: Breast Cancer Team Publications:

    Patella F, Schug ZT, Persi E, Neilson LJ, Erami Z, Avanzato D, Maione F, Hernandez-Fernaud JR, Mackay G, Zheng L, Reid S, Frezza C, Giraudo E, Fiorio Pla A, Anderson K, Ruppin E, Gottlieb E, Zanivan S. Proteomics-based metabolic modelling reveals that fatty acid oxidation controls endothelial cell permeability. Mol Cell Proteomics 14: 621-34, 2015

    van den Biggelaar M, Hernández-Fernaud JR, van den Eshof BL, Neilson LJ, Meijer AB, Mertens K, Zanivan S. Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells. Blood 123: e22-36, 2014

    Sara Zanivan

    Breast Cancer
    CRUK Beatson Institute
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    Simon Mackay

    Medicinal Chemistry
    Institution: University of Strathclyde Area of interest:

    Cancer drug discovery, in particular to identify small molecule inhibitors for the treatment of prostate cancer.

    Teams: Chemical Biology Team Prostate Cancer Team Publications:

    See Selected Publications

    Simon Mackay

    Chemical Biology, Prostate Cancer
    University of Strathclyde
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    Stephen Clark

    Institution: University of Glasgow Area of interest: Teams: Chemical Biology Team Publications:

    Stephen Clark

    Chemical Biology
    University of Glasgow
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    Susan Pyne

    Molecular Signalling
    Institution: University of Strathclyde Area of interest:

    The molecular mechanisms by which sphingosine 1-phosphate affects cell function in health and disease.

    Teams: Breast Cancer Team Publications:

    See Selected Publications

    Susan Pyne

    Breast Cancer
    University of Strathclyde
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    Tessa Holyoake

    Normal & Leukaemic Stem Cells
    Institution: University of Glasgow Area of interest:

    The identification and characterisation of normal versus leukaemic stem cells in chronic myeloid leukaemia.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Tessa Holyoake

    Leukaemia
    University of Glasgow
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    Torsten Stein

    Mammary Gland Morphogenesis & Breast Cancer
    Institution: University of Glasgow Area of interest:

    The molecular and cellular changes that occur during mammary gland development and how these are deregulated in breast cancer.

    Teams: Breast Cancer Team Publications:

    Link to Enlighten, University of Glasgow

    Torsten Stein

    Breast Cancer
    University of Glasgow
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    Vignir Helgason

    Leukaemia & Autophagy Therapeutics
    Institution: University of Glasgow Area of interest:

    The role of autophagy in disease persistence and drug resistance in CML.

    Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Vignir Helgason

    Leukaemia
    University of Glasgow
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    William Kerr

    Institution: University of Strathclyde Area of interest: Teams: Chemical Biology Team Publications:

    William Kerr

    Chemical Biology
    University of Strathclyde
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    Xu Huang

    Institution: University of Glasgow Area of interest: Teams: Leukaemias Team Publications:

    Link to Enlighten, University of Glasgow

    Xu Huang

    Leukaemia
    University of Glasgow